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ea0099p191 | Late-Breaking | ECE2024

Activating somatic ESR1 mutation in an aggressive prolactinoma

Silva Ticiana , Buelvas Mebarak Jacobo , C. Magnotto John , A. Stamatiades George , Kuang Yanan , Paweletz Cloud , R. Laws Edward , Stephanie Carroll Rona , Jeselsohn Rinath , Mohan Dipika , Marcondes Lerario Antonio , Truong Minh-Tam , Linda Bi Wenya , A. Reardon David , M. Meredith David , Kaiser Ursula , Paula Abreu Ana

Introduction: Prolactinomas are benign tumors usually well controlled with dopamine agonists; few progress on medical therapy through unclear molecular mechanisms. Although the SF3B1 mutation has been recently associated with aggressive prolactinomas, in most cases, no genetic mutations have been reported. We aimed to identify somatic genetic alterations associated with prolactinomas using a gene panel.Method and Results: Oncopanel, a massively ...

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Activating somatic ESR1 mutation in an aggressive prolactinoma

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